Kirk J McManus Selected Research

Chromosomal Instability (Chromosome Stability)

1/2022	The F-box protein, FBXO7, is required to maintain chromosome stability in humans.
1/2022	Aberrant SKP1 Expression: Diverse Mechanisms Impacting Genome and Chromosome Stability.
3/2021	Reduced USP22 Expression Impairs Mitotic Removal of H2B Monoubiquitination, Alters Chromatin Compaction and Induces Chromosome Instability That May Promote Oncogenesis.
2/2020	Reduced SKP1 Expression Induces Chromosome Instability through Aberrant Cyclin E1 Protein Turnover.
7/2019	Diminished Condensin Gene Expression Drives Chromosome Instability That May Contribute to Colorectal Cancer Pathogenesis.
1/2018	Characterizing Microsatellite Instability and Chromosome Instability in Interval Colorectal Cancers.
1/2014	Sequencing of candidate chromosome instability genes in endometrial cancers reveals somatic mutations in ESCO1, CHTF18, and MRE11A.
11/2013	Synthetic lethal targeting of superoxide dismutase 1 selectively kills RAD54B-deficient colorectal cancer cells.
8/2013	Sister chromatid cohesion defects are associated with chromosome instability in Hodgkin lymphoma cells.
1/2013	An evolutionarily conserved synthetic lethal interaction network identifies FEN1 as a broad-spectrum target for anticancer therapeutic development.

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Kirk J McManus Research Topics

Disease

23	Neoplasms (Cancer) 11/2022 - 03/2009
10	Chromosomal Instability (Chromosome Stability) 01/2022 - 01/2013
9	Genomic Instability 01/2022 - 07/2008
8	Carcinogenesis 01/2022 - 08/2011
5	Colorectal Neoplasms (Colorectal Cancer) 07/2019 - 01/2013
2	Aneuploidy (Aneuploid) 01/2021 - 08/2011
1	Breast Neoplasms (Breast Cancer) 01/2022
1	Retinoblastoma (Glioblastoma, Retinal) 01/2022
1	Carcinoma (Carcinomatosis) 01/2021
1	Ovarian Epithelial Carcinoma 01/2021
1	Disease Progression 01/2021
1	Polyps 01/2018
1	Microsatellite Instability 01/2018
1	Fibrosarcoma 01/2015
1	Hypersensitivity (Allergy) 08/2011

Drug/Important Bio-Agent (IBA)

9	Pharmaceutical PreparationsIBA 11/2022 - 11/2013
7	Proteins (Proteins, Gene)FDA Link 01/2022 - 03/2009
5	Histones (Histone)IBA 01/2019 - 07/2008
3	DNA (Deoxyribonucleic Acid)IBA 11/2022 - 09/2015
2	Deubiquitinating EnzymesIBA 11/2022 - 03/2021
2	Calcibiotic Root Canal SealerIBA 01/2022 - 01/2018
2	F-Box ProteinsIBA 01/2022 - 08/2021
2	ChromatinIBA 03/2021 - 12/2013
2	Lysine (L-Lysine)FDA Link 02/2015 - 07/2008
1	UbiquitinIBA 11/2022
1	Ligases (Synthetase)IBA 11/2022
1	Estrogen ReceptorsIBA 01/2022
1	Estradiol (Delestrogen)FDA LinkGeneric 01/2022
1	Estrogens (Estrogen)FDA Link 01/2022
1	Indicators and Reagents (Reagents)IBA 01/2022
1	Transcription Factors (Transcription Factor)IBA 12/2021
1	Messenger RNA (mRNA)IBA 12/2021
1	Oncogene Proteins (Oncogene Protein)IBA 12/2021
1	PlatinumIBA 01/2021
1	CyclinsIBA 02/2020
1	condensin complexes (condensin)IBA 07/2019
1	Ubiquitin-Specific ProteasesIBA 12/2017
1	Reactive Oxygen Species (Oxygen Radicals)IBA 09/2015
1	Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase)IBA 02/2015
1	fluorescent protein 583IBA 01/2015
1	Biological ProductsIBA 10/2014
1	NucleotidesIBA 01/2014
1	Superoxide Dismutase-1IBA 11/2013
1	Complement System Proteins (Complement)IBA 08/2013
1	Small Interfering RNA (siRNA)IBA 01/2013
1	Flap EndonucleasesIBA 01/2013
1	Proliferating Cell Nuclear Antigen (PCNA)IBA 08/2011
1	Nonsense Codon (Nonsense Mutation)IBA 08/2011

Therapy/Procedure

4	Precision Medicine 11/2022 - 06/2013
4	Therapeutics 02/2019 - 11/2017
3	Drug Therapy (Chemotherapy) 01/2021 - 12/2016
1	Hormone Replacement Therapy (Therapy, Hormone Replacement) 01/2022